Abstract
A series of potent and orally bioavailable 3,4-diaminocyclobutenediones with various amide modifications and substitution on the left side phenyl ring were prepared and found to show significant inhibitory activities towards both CXCR2 and CXCR1 receptors.
MeSH terms
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Administration, Oral
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Amides / chemistry*
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Animals
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Area Under Curve
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Chemistry, Pharmaceutical / methods
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Cyclobutanes / chemical synthesis*
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Cyclobutanes / pharmacology
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Diamines / chemical synthesis*
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Diamines / pharmacology
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Drug Design
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Humans
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Inflammation
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Kinetics
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Models, Chemical
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Phenol / chemistry*
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Rats
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Receptors, Interleukin-8A / antagonists & inhibitors*
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Receptors, Interleukin-8B / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Amides
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Cyclobutanes
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Diamines
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Receptors, Interleukin-8A
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Receptors, Interleukin-8B
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Phenol